Application
Western blot analysis of NOD1 in EL4 cell lysate with NOD1 antibody at 1 μg/mL.| Product Name | NOD1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NOD1 Antibody: CARD4, NLRC1, CLR7.1, Caspase recruitment domain-containing protein 4, Nucleotide-binding oligomerization domain-containing protein 1 |
| Product description | NOD1 Antibody: NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD1 contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and ten tandem leucine-rich repeats (LRRs) in its C-terminus. The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-κB. LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.1) Kufer TA, Banks DJ, and Philpott DJ. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci.2006; 1072:19-27. |
| Immunogen | NOD1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy end of human NOD1. The immunogen is located within the last 50 amino acids of NOD1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| NOD1 antibody can be used for detection of NOD1 by Western blot at 1 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NOD1 |
|---|---|
| Alternative Names | NOD1 Antibody: CARD4 NLRC1 CLR7.1 Caspase recruitment domain-containing protein 4 Nucleotide-binding oligomerization domain-containing protein 1 |
Application
Western blot analysis of NOD1 in EL4 cell lysate with NOD1 antibody at 1 μg/mL.| Positive Control | 1) Cat. No. 1287 - EL4 Cell Lysate |
|---|---|
| Application Notes | NOD1 antibody can be used for detection of NOD1 by Western blot at 1 μg/mL.: |
| Form | Liquid |
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| Storage Instructions | NOD1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | NOD1 Antibody is supplied in PBS containing 0.02% sodium azide. |
