Application
Western blot analysis in K562,MDA-MB453,NCI-H292,A549,293,Hela,CEM,NCI-H460 cell line and human nomal uterus tissue lysates (35ug/lane).| Product Name | PARP3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Poly [ADP-ribose] polymerase 3, PARP-3, hPARP-3, ADP-ribosyltransferase diphtheria toxin-like 3, ARTD3, IRT1, NAD(+) ADP-ribosyltransferase 3, ADPRT-3, Poly[ADP-ribose] synthase 3, pADPRT-3, PARP3, ADPRT3, ADPRTL3 |
| Product description | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. |
| Immunogen | This PARP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-126 amino acids from the N-terminal region of human PARP3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PARP3 |
|---|---|
| Alternative Names | Poly [ADP-ribose] polymerase 3 PARP-3 hPARP-3 ADP-ribosyltransferase diphtheria toxin-like 3 ARTD3 IRT1 NAD(+) ADP-ribosyltransferase 3 ADPRT-3 Poly[ADP-ribose] synthase 3 pADPRT-3 PARP3 ADPRT3 ADPRTL3 |
| Molecular Weight(MW) | 60 kDa |
Application
Western blot analysis in K562,MDA-MB453,NCI-H292,A549,293,Hela,CEM,NCI-H460 cell line and human nomal uterus tissue lysates (35ug/lane).| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
