Application
Immunohistochemical staining of human brain tissue using Plxdc2 antibody at 2.5 μg/mL.Application
Immunofluorescence of Plxdc2 in Human Brain cells with Plxdc2 antibody at 50 μg/mL.Application
Western blot analysis of Plxdc2 in human colon tissue lysate with Plxdc2 antibody at (A) 0.5 (B) 1 μg/mL.| Product Name | Plxdc2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Plxdc2 Antibody: TEM7R, TEM7R, UNQ2514/PRO6003, Plexin domain-containing protein 2, Tumor endothelial marker 7-related protein |
| Product description | Plxdc2 Antibody: Plxdc2, also known as Tumor endothelial marker 7-related (TEM7R) encodes a protein with 57% amino acid identity to TEM7, the most abundant tumor endothelial marker. Plxdc2 is strongly expressed in the endothelial cells of the tumor stroma, but not in the endothelial cells of normal colonic tissue. Plxdc2 is also expressed at high levels in vessels of some normal tissues, with highest expression in muscle and lung. Plxdc2 and TEM7 may be important for tumor angiogenesis in humans. Cortactin was identified as a protein capable of binding to the extracellular region of both TEM7 and Plxdc2, and may provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors.1) Carson-Weber EB, Watkins DN, Nanda A, et al. Cell surface tumor epithelial markers are conserved in mice and humans. Cancer Res.2001; 61:6649-55. |
| Immunogen | Plxdc2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human Plxdc2. The immunogen is located within the last 50 amino acids of Plxdc2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| Plxdc2 antibody can be used for detection of Plxdc2 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PLXDC2 |
|---|---|
| Alternative Names | Plxdc2 Antibody: TEM7R TEM7R UNQ2514/PRO6003 Plexin domain-containing protein 2 Tumor endothelial marker 7-related protein |
| Sequence Similarities | 2) Cat. No. 10-301 - Human Brain Tissue Slide |
Application
Immunohistochemical staining of human brain tissue using Plxdc2 antibody at 2.5 μg/mL.
Application
Immunofluorescence of Plxdc2 in Human Brain cells with Plxdc2 antibody at 50 μg/mL.
Application
Western blot analysis of Plxdc2 in human colon tissue lysate with Plxdc2 antibody at (A) 0.5 (B) 1 μg/mL.| Positive Control | 1) Cat. No. 1320 - Human Colon Tissue Lysate |
|---|---|
| Application Notes | Plxdc2 antibody can be used for detection of Plxdc2 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Plxdc2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Plxdc2 Antibody is supplied in PBS containing 0.02% sodium azide. |
