Application
Immunohistochemistry staining of PMSA in prostate tissue using PMSA monoclonal Antibody.| Product Name | PMSA Antibody, Monoclonal |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FOLH1, Folate hydrolase 1, GCPII, Glutamate carboxypeptidase II, Folate hydrolase, GCP2, NAALAD1, NAALAdase, NAALADase I, PSM, FGCP, FOLH, Glutamate carboxylase II, Glutamate carboxypeptidase 2, MGCP, PSMA |
| Product description | PSMA (prostate specific membrane antigen) is a type II integral membrane glycoprotein. It is highly expressed in the prostate epithelium, and also expressed in the small intestine, brain, kidney, liver, spleen, colon and the capillary endothelium of a variety of tumors. PSMA is expressed specifically in jejunum brush border membranes. In the brain, PSMA is highly expressed in the ventral striatum and brain stem. PSMA cytosolic isoform is the most abundant form in normal prostate tissue, while the membrane-bound PSMA-1 form is found in primary prostate tumors. Recent evidence has shown that PSMA is also expressed in tumor-associated neovasculature and may become an effective target for monoclonal antibody-based anti-neovasculature therapy. Suitable for use in ELISA, Immunohistochemistry (FFPE), and Western Blot. Other applications not tested. Recognizes human PSMA protein at ~90kD. Reactivity has been confirmed with human prostate cancer LNCap cell lysates. |
| Immunogen | PMSA monoclonal antibody was raised against a synthetic peptide derived from the C-Terminal region of human PSMA (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1, k |
| Host Species | Mouse |
| Tested Applications | ELISAIHCWB |
| PMSA antibody can be used in Western Blot starting at 2 - 4 μg/mL, immunohistochemistry starting at 5 μg/mL, flow cytometry, and neutralization: |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | FOLH1 |
|---|---|
| Alternative Names | FOLH1 Folate hydrolase 1 GCPII Glutamate carboxypeptidase II Folate hydrolase GCP2 NAALAD1 NAALAdase NAALADase I PSM FGCP FOLH Glutamate carboxylase II Glutamate carboxypeptidase 2 MGCP PSMA |
| Tissue Specificity | Recognizes human PSMA protein at ~90kD. Reactivity has been confirmed with human prostate cancer LNCap cell lysates. |
Application
Immunohistochemistry staining of PMSA in prostate tissue using PMSA monoclonal Antibody.| Application Notes | PMSA antibody can be used in Western Blot starting at 2 - 4 μg/mL, immunohistochemistry starting at 5 μg/mL, flow cytometry, and neutralization: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | PMSA antibody should be stored long term (months) at -20 ˚C and short term (weeks) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, pH 7.4, 0.1% sodium azide, before the addition of glycerol to 40% |
