The protein encoded by this gene is a member of the PP2C
family of Ser/Thr protein phosphatases. PP2C family members are
known to be negative regulators of cell stress response pathways.
This phosphatase is found to be responsible for the
dephosphorylation of Pre-mRNA splicing factors, which is important
for the formation of functional spliceosome. Studies of a similar
gene in mice suggested a role of this phosphatase in regulating
cell cycle progression.1) Dick, D.M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
Immunogen
This PPM1G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the N-terminal region of human PPM1G.
Protein phosphatase 1G Protein phosphatase 1C Protein phosphatase 2C isoform gamma PP2C-gamma Protein phosphatase magnesium-dependent 1 gamma PPM1G PPM1C
Molecular Weight(MW)
59 kDa
Sequence Similarities
Predicted species reactivity based on immunogen sequence: Bovine
Western blot analysis in HepG2 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.