Application
Immunofluorescence of PTGDR2 in human small intestine tissue with PTGDR2 antibody at 20 μg/ml.Application
Western blot analysis of PTGDR2 in small intestine tissue lysate with PTGDR2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Product Name | PTGDR2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PTGDR2 Antibody: DP2, DL1R, CD294, CRTH2, GPR44, Prostaglandin D2 receptor 2, Chemoattractant receptor-homologous molecule expressed on Th2 cells |
| Product description | PTGDR2 Antibody: The prostaglandin D2 receptor 2 (PTGDR2), also known as CRTH2, is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, PTGDR2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the PTGDR2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that PTGDR2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo.1) Nagata K, Hirai K, Tanaka K, et al. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett. 1999; 459:195-9. |
| Immunogen | Rabbit polyclonal PTGDR2 antibody was raised against a 19 amino acid peptide near the center of human PTGDR2. The immunogen is located within amino acids 320 - 370 of PTGDR2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFWB |
| PTGDR2 antibody can be used for detection of PTGDR2 by Western blot at 0.5 - 1 μg/mL.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PTGDR2 |
|---|---|
| Alternative Names | PTGDR2 Antibody: DP2 DL1R CD294 CRTH2 GPR44 Prostaglandin D2 receptor 2 Chemoattractant receptor-homologous molecule expressed on Th2 cells |
| Molecular Weight(MW) | Predicted: 43 kDa |
| Sequence Similarities | 2) Cat. No. 11-801 - Human Small Intestine Tissue Slide |
Application
Immunofluorescence of PTGDR2 in human small intestine tissue with PTGDR2 antibody at 20 μg/ml.
Application
Western blot analysis of PTGDR2 in small intestine tissue lysate with PTGDR2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Positive Control | 1) Cat. No. 1308 - Human Small Intestine Tissue Lysate |
|---|---|
| Application Notes | PTGDR2 antibody can be used for detection of PTGDR2 by Western blot at 0.5 - 1 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | PTGDR2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | PTGDR2 Antibody is supplied in PBS containing 0.02% sodium azide. |
