Application
Immunohistochemistry staining of Ring-box 1 in liver tissue using Ring-box 1 Antibody.| Product Name | Ring-box 1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RBX1, Regulator of cullins 1, RING box protein 1, ROC1, TESTICAN, Ring-box 1, RNF75, BA554C12.1, Protein ZYP, RING finger protein 75, RING-box protein 1, ZYP protein |
| Product description | ROC1 also known as RING-box protein 1, Rbx1, Regulator of cullins 1, RING finger protein 75, and ZYP protein, is a component of the SCF (SKP1-CUL1-F-box protein) and the CBC(VHL) (CUL2-elonging BC-VHL) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. ROC1 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34, and brings it into close proximity to the substrate. The RING-type zinc finger domain is essential for ubiquitin ligase activity. ROC1 probably also stimulates CDC34 autoubiquitination and promotes the neddylation of CUL1 and probably CUL2. ROC1 has a cytoplasmic and nuclear localization and is widely expressed in most tissues. |
| Immunogen | Ring - box 1 antibody was raised against amino acids 360 - 375 of Ring - box 1 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCIPWB |
| Ring-box 1 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 5 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | RBX1 |
|---|---|
| Alternative Names | RBX1 Regulator of cullins 1 RING box protein 1 ROC1 TESTICAN Ring-box 1 RNF75 BA554C12.1 Protein ZYP RING finger protein 75 RING-box protein 1 ZYP protein |
Application
Immunohistochemistry staining of Ring-box 1 in liver tissue using Ring-box 1 Antibody.| Application Notes | Ring-box 1 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 5 μg/mL.: |
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| Form | Liquid |
|---|---|
| Storage Instructions | Store Ring-box 1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.01% sodium azide. |
