Nuclear receptor coactivator 1, NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1, NCOA1, BHLHE74, SRC1
Product description
The protein encoded by this gene acts as a transcriptional
coactivator for steroid and nuclear hormone receptors. It is a
member of the p160/steroid receptor coactivator (SRC) family and
like other family members has histone acetyltransferase activity
and contains a nuclear localization signal, as well as bHLH and PAS
domains. The product of this gene binds nuclear receptors directly
and stimulates the transcriptional activities in a
hormone-dependent fashion. Alternatively spliced transcript
variants encoding different isoforms have been identified.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This SRC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 594-625 amino acids from the Central region of human SRC1.
Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.