| Product description |
STIM-1 is a component of the Ca sensor/channel. It associates with ORAI-1 and form a essential complex involved in store-operated channels. STIM1 activates Ca(2+) influx via Orai1 channels. Expression of STIM and Orai proteins are found in many cell types and knock-out mice lack viability.1) Williams RT, Senior PV, Van Stekelenburg L, Layton JE, Smith PJ, Dziadek MA., Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation., Biochim Biophys Acta. 2002 Apr 1;1596(1):131-137 |