Application
Immunohistochemistry staining of TIRAP in skeletal muscle tissue using TIRAP Antibody.| Product Name | TIRAP Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TIRAP, Adapter protein wyatt, BACTS1, Adaptor protein Wyatt, MyD88 adapter-like protein, Wyatt |
| Product description | Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-κB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling. |
| Immunogen | TIRAP antibody was raised against a synthetic peptide corresponding to N-Terminal residues of TIRAP (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| TIRAP antibody can be used in ELISA starting at 1:15000 - 1:60000, Western Blot, immunohistochemistry starting at 2.5 μg/mL, and immunofluorescence.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TIRAP |
|---|---|
| Alternative Names | TIRAP Adapter protein wyatt BACTS1 Adaptor protein Wyatt MyD88 adapter-like protein Wyatt |
Application
Immunohistochemistry staining of TIRAP in skeletal muscle tissue using TIRAP Antibody.| Application Notes | TIRAP antibody can be used in ELISA starting at 1:15000 - 1:60000, Western Blot, immunohistochemistry starting at 2.5 μg/mL, and immunofluorescence.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store TIRAP antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.01% sodium azide, 50% glycerol. |
