| Product Name | Anti-Phospho-TIRAP (Tyr106) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Tyr106 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TIRAP |
|---|---|
| Gene Synonyms | Mal wyatt BACTS1 MyD88-2 |
| Gene Full Name | TIR domain containing adaptor protein |
| Gene Summary | The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] |
| Alternative Names | Adapter protein wyatt FLJ42305 MAL MyD88 adapter like protein TIR domain containing adapter protein Toll interleukin 1 receptor (TIR) domain containing adaptor protein Toll interleukin 1 receptor domain containing adapter protein Toll like receptor adaptor protein Wyatt |
| Molecular Weight(MW) | 24 kDa |
| Cellular Localization | Cell membrane, Cytoplasm, Membrane. |
| SwissProt ID | P58753 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
