Application
Immunohistochemistry staining of TNFRSF10B in breast tissue using TNFRSF10B Antibody.| Product Name | TNFRSF10B Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TNFRSF10B, Cytotoxic TRAIL receptor-2, CD262 antigen, DR5, Death receptor 5, KILLER, TRAIL-R2, TRICK2B, TRAILR2, TRICK2A, TRICKB, TRICK2, CD262, Fas-like protein, TRAIL receptor 2, ZTNFR9 |
| Product description | Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-2). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κB. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κB. |
| Immunogen | TNFRSF10B antibody was raised against amino acids 388 - 407 of TNFRSF10B (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | FACSICCIHCWB |
| TNFRSF10B antibody can be used in Western Blot, immunohistochemistry starting at 20 μg/mL, and immunoprecipitation.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | TNFRSF10B |
|---|---|
| Alternative Names | TNFRSF10B Cytotoxic TRAIL receptor-2 CD262 antigen DR5 Death receptor 5 KILLER TRAIL-R2 TRICK2B TRAILR2 TRICK2A TRICKB TRICK2 CD262 Fas-like protein TRAIL receptor 2 ZTNFR9 |
Application
Immunohistochemistry staining of TNFRSF10B in breast tissue using TNFRSF10B Antibody.| Application Notes | TNFRSF10B antibody can be used in Western Blot, immunohistochemistry starting at 20 μg/mL, and immunoprecipitation.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | TNFRSF10B antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.05% BSA, 0.05% sodium azide. |
