| Product Name | TRAIL-R2 Antibody (preservative free) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRAIL Receptor 2; DR5; KILLER; TNFRSF10B; CD262 |
| Product description | TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. |
| Immunogen | Recombinant human TRAIL-R2 (DR5). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | FACSFunctionalStudiesICCIP |
| Functional Application: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution).: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TNFRSF10B |
|---|---|
| Alternative Names | TRAIL Receptor 2 DR5 KILLER TNFRSF10B CD262 |
| Tissue Specificity | Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4. |
| Application Notes | Functional Application: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution).: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. In PBS containing 10% glycerol. Preservative free formulation. |
