TNFSF13, APRIL, CD256, CD256 antigen, TALL-2, TALL2, ZTNF2, TNF-related death ligand 1, TRDL-1, UNQ383/PRO715
Product description
APRIL (a proliferation-inducing ligand) is a newly identified member of the tumor necrosis factor (TNF) family. Ectopic expression of APRIL is associated with the upregulation of X-linked inhibitor of apoptosis protein (XIAP) and may act as antiapoptotic factor. Although transcripts of APRIL are of low abundance in normal tissues, high levels of mRNA are detected in transformed cell lines, and in human cancers of colon, thyroid, and lymphoid tissues in vivo. Northern blot analysis revealed weak expression restricted to a few tissues: transcripts of 2.1 and 2.4 kb in prostate and a transcript of 1.8 kb in peripheral blood leukocytes. All tumor cell lines, however, strongly expressed the TNFSF13 2.1-kb transcript, and expression of extracellular or full-length TNFSF13 led to increased proliferation of various cell lines.
Immunogen
TNFSF13 antibody was raised against amino acids 1 - 17 of TNFSF13 (Human).
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCWB
TNFSF13 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL.: