Application
Immunohistochemistry staining of TNFSF13B in tonsil tissue using TNFSF13B Antibody.| Product Name | TNFSF13B Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TNFSF13B, B-cell-activating factor, BAFF, ApoL related ligand TALL-1, B-lymphocyte stimulator, CD257, BLYS, Delta4 BAFF, Delta BAFF, TALL-1, TALL1, ZTNF4, THANK, B lymphocyte stimulator, CD257 antigen, TNFSF20 |
| Product description | Simultaneously four different laboratories identified a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 , THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase , BAFF (for B cell activating factor belonging to the TNF family) and Blys (B lymphocyte stimulator). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. Secreted BLyS/BAFF/THANK acts as a potent B cell growth factor. Overexpression of BLyS/BAFF in transgenic mice lead to increased numbers of mature B and effector T cells. These mice also develop autoimmune like symptoms, such as, high levels of rheumatoid factors, anti-DNA autoantibodies, etc.. Recently, two receptors for BLyS/BAFF have been identified and termed as BCMA and TACI. Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-κB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. |
| Immunogen | TNFSF13B antibody was raised against amino acids 254 - 269 of TNFSF13B (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| TNFSF13B antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL.: |
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| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | TNFSF13B |
|---|---|
| Alternative Names | TNFSF13B B-cell-activating factor BAFF ApoL related ligand TALL-1 B-lymphocyte stimulator CD257 BLYS Delta4 BAFF Delta BAFF TALL-1 TALL1 ZTNF4 THANK B lymphocyte stimulator CD257 antigen TNFSF20 |
Application
Immunohistochemistry staining of TNFSF13B in tonsil tissue using TNFSF13B Antibody.| Application Notes | TNFSF13B antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL.: |
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| Form | Liquid |
|---|---|
| Storage Instructions | TNFSF13B antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 200 μL PBS containing 0.05% BSA, 0.05% sodium azide. |
