Application
Immunohistochemistry staining of TRAF5 in breast tissue using TRAF5 monoclonal Antibody.| Product Name | TRAF5 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRAF5, RNF84, MGC:39780, RING finger protein 84 |
| Product description | Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-κB and c-Jun NH-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymhocyte activation. |
| Immunogen | TRAF5 monoclonal antibody was raised against amino acids 77 - 186 of TRAF5 (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Mouse |
| Tested Applications | WB |
| TRAF5 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | TRAF5 |
|---|---|
| Alternative Names | TRAF5 RNF84 MGC:39780 RING finger protein 84 |
Application
Immunohistochemistry staining of TRAF5 in breast tissue using TRAF5 monoclonal Antibody.| Application Notes | TRAF5 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | TRAF5 antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.02% sodium azide. |
