| Product Name | TRIF Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Toll-interleukin-1 Receptor [TIR] Domain-containing Adapter Inducing Interferon-beta; TICAM-1; TIR-containing Adaptor Molecule-1 |
| Product description | TRIF is involved in innate immunity against invading pathogens. It is an adaptor used by TLR3 and TLR4 (through TICAM-2) to mediate NF-kappaB and interferon-regulatory factor (IRF) activation and to induce apoptosis. Ligand binding to TLR3 and TLR4 results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappaB and FADD respectively. TRIF is ubiquitously expressed with higher levels in liver. |
| Immunogen | Synthetic peptide corresponding to aa 4-31 (T4GPSLPSAFDILGAAGQDKLLYLKHKLK31) of N-terminal human TRIF. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IPWB |
| Western Blot:(1:1,000).: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | TICAM1 |
|---|---|
| Alternative Names | Toll-interleukin-1 Receptor [TIR] Domain-containing Adapter Inducing Interferon-beta TICAM-1 TIR-containing Adaptor Molecule-1 |
| Tissue Specificity | Recognizes human TRIF. |
| Application Notes | Western Blot:(1:1,000).: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. In PBS containing 0.02% sodium azide. |
