Application
Western blot analysis using TYK2 monoclonal antibody against truncated TYK2 recombinant protein and Jurkat cell lysate.| Product Name | Tyk2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | JTK1 |
| Product description | Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131 kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-α, IFN-β, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.1) Michael H. Shaw, Gordon J. Freeman, Mark F. Scott. J. Immunol., Jun 2006; 176: 7263-7271. |
| Immunogen | Ni-NTA purified truncated recombinant Tyk2 expressed in E. Coli strain BL21 (DE3). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ELISAWB |
| Western Blot:1:500 - 1:2,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | TYK2 |
|---|---|
| Alternative Names | JTK1 |
Application
Western blot analysis using TYK2 monoclonal antibody against truncated TYK2 recombinant protein and Jurkat cell lysate.| Application Notes | Western Blot:1:500 - 1:2,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Tyk2 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Ascitic fluid containing 0.03% sodium azide. |
