| Product Name | ZAG Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Zn-alpha-2-GP; Zn-alpha-2-Glycoprotein; ZAG; ZA2G; AZGP1; ZNGP1 |
| Product description | Zinc-alpha-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vivo experiments. Due to its expression in and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes and it associates with prolactin inducible protein rather than beta2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its alpha1 and alpha2 domain helices. |
| Immunogen | Recombinant human zinc-alpha-2-glycoprotein. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ELISAWB |
| Flow Cytometry: (1:100). Definition for 1 test: 1ul of labeled antibody in 200ul of Flow Cytometry buffer (see online protocol).: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | AZGP1 |
|---|---|
| Alternative Names | Zn-alpha-2-GP Zn-alpha-2-Glycoprotein ZAG ZA2G AZGP1 ZNGP1 |
| Tissue Specificity | Recognizes human zinc-alpha-2-glycoprotein. |
| Application Notes | Flow Cytometry: (1:100). Definition for 1 test: 1ul of labeled antibody in 200ul of Flow Cytometry buffer (see online protocol).: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
Data sheet for OM295349