| Product Name | Phospho-TRAF2 (Ser11) (E2B6L) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TNF receptor associated factor 2; TNF receptor-associated factor 2; TNF receptor-associated protein; TRAF 2; TRAF2; TRAF2_HUMAN; TRAP 3; TRAP; TRAP3; Tumor necrosis factor type 2 receptor associated protein 3; |
| Product description | Tumor necrosis factor (TNF)-activated cell signaling is mediated primarily through the TNF receptor 1 (TNF-R1) and, to a lesser extent, TNF-R2. Both TNF receptors are members of the expanding TNF receptor superfamily, which includes the FAS antigen and CD40. Potential insight into an understanding of TNF receptor-mediated signaling was provided by the identification of two related proteins, TRAF1 and TRAF2 (for TNF receptor-associated factors 1 and 2, respectively). Both function to form heterodimeric complexes and associate with the cytoplasmic domain of TNF-R2. A third member of this protein family, alternatively designated CD40 bp, CRAF1, LAP1 or TRAF3, has been identified and shown to associate with the cytoplasmic domain of CD40. The similarity between a specific region of TRAF3 with regions of TRAF1 and TRAF2 define a “TRAF-C” domain that is necessary and sufficient for CD40 binding and homodimerization. |
| Immunogen | epitope mapping at the N-terminus of TRAF2 of human origin |
| Modification | p-E2B6L |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TRAF2 |
|---|---|
| Alternative Names | TNF receptor associated factor 2 TNF receptor-associated factor 2 TNF receptor-associated protein TRAF 2 TRAF2 TRAF2_HUMAN TRAP 3 TRAP TRAP3 Tumor necrosis factor type 2 receptor associated protein 3 |
| Molecular Weight(MW) | 56kD |
| SwissProt ID | Q12933 |
|---|
| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Antibody may be stored short term at 4˚C, long term aliquot and store at -20˚C, avoid freeze thaw cycles. |
| Storage Buffer | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol |
