Application
Fig1: Western blot analysis of Ku70 on different cell lysates using anti-Ku70 antibody at 1/2000 dilution. Positive control: Lane 1: Hela Lane 2: HepG2 Lane 3: A431 Lane 4: D3 Lane 5: 293T Lane 6: A549 Lane 7: COS-1 Lane 8: Human kidney Lane 9: Human liver Lane 10: human brain Lane 11: Human thymus Lane 12: Human placentae Lane 13: Mouse kidney Lane 14: Mouse liver Lane 15: Mouse thymus Lane 16: Mouse testisApplication
Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Ku70 antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-Ku70 antibody. Counter stained with hematoxylin.| Product Name | Ku70 [D1-A6] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 5''-deoxyribose-5-phosphate lyase Ku70 antibody 5''-dRP lyase Ku70 antibody 70 kDa subunit of Ku antigen antibody ATP dependent DNA helicase 2 subunit 1 antibody ATP dependent DNA helicase II 70 kDa subunit antibody ATP-dependent DNA helicase 2 subunit 1 antibody ATP-dependent DNA helicase II 70 kDa subunit antibody CTC box binding factor 75 kDa subunit antibody CTC box-binding factor 75 kDa subunit antibody CTC75 antibody CTCBF antibody DNA repair protein XRCC6 antibody G22P1 antibody Ku 70 antibody Ku autoantigen p70 subunit antibody Ku autoantigen, 70kDa antibody Ku p70 antibody Ku70 antibody Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody Kup70 antibody Lupus Ku autoantigen protein p70 antibody ML8 antibody Thyroid autoantigen 70kD (Ku antigen) antibody Thyroid autoantigen antibody Thyroid lupus autoantigen antibody Thyroid lupus autoantigen p70 antibody Thyroid-lupus autoantigen antibody TLAA antibody X ray repair complementing defective repair in Chinese hamster cells 6 antibody X-ray repair complementing defective repair in Chinese hamster cells 6 antibody X-ray repair cross-complementing protein 6 antibody XRCC 6 antibody Xrcc6 antibody XRCC6_HUMAN antibody |
| Product description | Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:2,000 IHC:1:100-1:200 |
|
| Species Reactivity | HumanMouse |
| Concentration | 2mg/ml |
| Alternative Names | 5''-deoxyribose-5-phosphate lyase Ku70 antibody
5''-dRP lyase Ku70 antibody
70 kDa subunit of Ku antigen antibody
ATP dependent DNA helicase 2 subunit 1 antibody
ATP dependent DNA helicase II 70 kDa subunit antibody
ATP-dependent DNA helicase 2 subunit 1 antibody
ATP-dependent DNA helicase II 70 kDa subunit antibody
CTC box binding factor 75 kDa subunit antibody
CTC box-binding factor 75 kDa subunit antibody
CTC75 antibody
CTCBF antibody
DNA repair protein XRCC6 antibody
G22P1 antibody
Ku 70 antibody
Ku autoantigen p70 subunit antibody
Ku autoantigen 70kDa antibody Ku p70 antibody Ku70 antibody Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody Kup70 antibody Lupus Ku autoantigen protein p70 antibody ML8 antibody Thyroid autoantigen 70kD (Ku antigen) antibody Thyroid autoantigen antibody Thyroid lupus autoantigen antibody Thyroid lupus autoantigen p70 antibody Thyroid-lupus autoantigen antibody TLAA antibody X ray repair complementing defective repair in Chinese hamster cells 6 antibody X-ray repair complementing defective repair in Chinese hamster cells 6 antibody X-ray repair cross-complementing protein 6 antibody XRCC 6 antibody Xrcc6 antibody XRCC6_HUMAN antibody |
|---|---|
| Molecular Weight(MW) | 70 kDa |
| Cellular Localization | Nucleus |
| SwissProt ID | P12956 |
|---|
Application
Fig1: Western blot analysis of Ku70 on different cell lysates using anti-Ku70 antibody at 1/2000 dilution. Positive control: Lane 1: Hela Lane 2: HepG2 Lane 3: A431 Lane 4: D3 Lane 5: 293T Lane 6: A549 Lane 7: COS-1 Lane 8: Human kidney Lane 9: Human liver Lane 10: human brain Lane 11: Human thymus Lane 12: Human placentae Lane 13: Mouse kidney Lane 14: Mouse liver Lane 15: Mouse thymus Lane 16: Mouse testis
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Ku70 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-Ku70 antibody. Counter stained with hematoxylin.| Positive Control | Hela, HepG2, A431, D3, 293T, A549, COS-1, human kidney tissue, human liver tissue, human brain, human thymus tissue, human placentae tissue, mouse kidney tissue, mouse liver tissue, mouse thymus tissue, mouse testis tissue, human tonsil tissue,human breast cancer tissue. |
|---|---|
| Application Notes | WB:1:2,000 IHC:1:100-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
