Application
Fig1: Western blot analysis of Protein FAM38A on recombinant protein using anti-Protein FAM38A antibody at 1/1000 dilution.Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Protein FAM38A antibody. Counter stained with hematoxylin.Application
Fig3: ICC staining Protein FAM38A (green) in A431 cells. Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Product Name | Protein FAM38A [2-10] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DHS Fam38a Family with sequence similarity 38 member A KIAA0233 Membrane protein induced by beta-amyloid treatment Mib PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component 1 PIEZO1 Protein FAM38A Protein FAM38B Protein PIEZO1 |
| Product description | Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. |
| Immunogen | Recombinant protein. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Host Species | Mouse |
| Tested Applications | WBIHCICC |
| WB:1:250~1:1000 IHC:1:20~1:100 ICC:1:100~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouse |
| Concentration | 2mg/ml |
| Alternative Names | DHS
Fam38a Family with sequence similarity 38 member A KIAA0233 Membrane protein induced by beta-amyloid treatment Mib PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component 1 PIEZO1 Protein FAM38A Protein FAM38B Protein PIEZO1 |
|---|---|
| Molecular Weight(MW) | 287 kDa |
| Cellular Localization | Endoplasmic reticulum membrane. Cell membrane. |
| SwissProt ID | Q92508 |
|---|
Application
Fig1: Western blot analysis of Protein FAM38A on recombinant protein using anti-Protein FAM38A antibody at 1/1000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Protein FAM38A antibody. Counter stained with hematoxylin.
Application
Fig3: ICC staining Protein FAM38A (green) in A431 cells. Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Positive Control | Recombinant protein, mouse brain tissue, A431. |
|---|---|
| Application Notes | WB:1:250~1:1000 IHC:1:20~1:100 ICC:1:100~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide. |
