Application
Fig1: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti- BRCA2 mouse mAb.Application
Fig2: ICC staining BRCA2 in MCF-7 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (blue).| Product Name | BRCA2 [A2-B10] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BRCA 2 antibody BRCA1/BRCA2 containing complex subunit 2 antibody Brca2 antibody BRCA2, DNA repair associated antibody BRCA2_HUMAN antibody BRCC 2 antibody BRCC2 antibody Breast and ovarian cancer susceptibility gene early onset antibody breast and ovarian cancer susceptibility protein 2 antibody Breast cancer 2 early onset antibody Breast Cancer 2 tumor suppressor antibody Breast cancer susceptibility protein BRCA2 antibody Breast cancer type 2 susceptibility protein antibody BROVCA2 antibody FACD antibody FAD 1 antibody FAD antibody FAD1 antibody FANCB antibody FANCD 1 antibody FANCD antibody FANCD1 antibody FANCD1 gene antibody Fanconi anemia complementation group D1 antibody Fanconi anemia group D1 protein antibody GLM3 antibody mutant BRCA2 antibody OTTHUMP00000018803 antibody OTTHUMP00000042401 antibody PNCA2 antibody XRCC11 antibody |
| Product description | BRCA2 (breast cancer type 2 susceptibility protein) belongs to the tumor suppressor gene family, and orthologs have been identified in most mammals for which complete genome data are available. The protein encoded by this gene is involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double strand breaks. Certain variations of the BRCA2 gene increase risks for breast cancer as part of a hereditary breast-ovarian cancer syndrome. Researchers have identified hundreds of mutations in the BRCA2 gene, many of which cause an increased risk of cancer. BRCA2 mutations are usually insertions or deletions of a small number of DNA base pairs in the gene. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ICCIHC |
| ICC:1:200 IHC:1:200 |
|
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | BRCA 2 antibody
BRCA1/BRCA2 containing complex subunit 2 antibody
Brca2 antibody
BRCA2 DNA repair associated antibody BRCA2_HUMAN antibody BRCC 2 antibody BRCC2 antibody Breast and ovarian cancer susceptibility gene early onset antibody breast and ovarian cancer susceptibility protein 2 antibody Breast cancer 2 early onset antibody Breast Cancer 2 tumor suppressor antibody Breast cancer susceptibility protein BRCA2 antibody Breast cancer type 2 susceptibility protein antibody BROVCA2 antibody FACD antibody FAD 1 antibody FAD antibody FAD1 antibody FANCB antibody FANCD 1 antibody FANCD antibody FANCD1 antibody FANCD1 gene antibody Fanconi anemia complementation group D1 antibody Fanconi anemia group D1 protein antibody GLM3 antibody mutant BRCA2 antibody OTTHUMP00000018803 antibody OTTHUMP00000042401 antibody PNCA2 antibody XRCC11 antibody |
|---|---|
| Cellular Localization | Nucleus, cytoplasm |
| SwissProt ID | P51587 |
|---|
Application
Fig1: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti- BRCA2 mouse mAb.
Application
Fig2: ICC staining BRCA2 in MCF-7 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (blue).| Positive Control | MCF-7, human breast carcinoma tissue |
|---|---|
| Application Notes | ICC:1:200 IHC:1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
