Application
Fig1: ICC staining CCDC111 in HepG2 cells(red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.Application
Fig2: Immunohistochemical analysis of paraffin-embedded human colonic tissue using anti- CCDC111 mouse monoclonal antibody.| Product Name | CCDC111 [10-B3] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CC111_HUMAN antibody CCDC111 antibody Coiled coil domain containing 111 antibody Coiled-coil domain-containing protein 111 antibody DNA-directed primase/polymerase protein antibody MYP22 antibody Primase and polymerase (DNA directed) antibody PRIMPOL antibody |
| Product description | DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. PRIMPOL shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. It is involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. PRIMPOL is required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. PRIMPOL has non-overlapping function with POLH. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ICCIHC |
| ICC:1:100-1:200 IHC:1:200 |
|
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | CC111_HUMAN antibody CCDC111 antibody Coiled coil domain containing 111 antibody Coiled-coil domain-containing protein 111 antibody DNA-directed primase/polymerase protein antibody MYP22 antibody Primase and polymerase (DNA directed) antibody PRIMPOL antibody |
|---|---|
| Molecular Weight(MW) | 64kDa |
| Cellular Localization | Nucleus |
| SwissProt ID | Q96LW4 |
|---|
Application
Fig1: ICC staining CCDC111 in HepG2 cells(red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human colonic tissue using anti- CCDC111 mouse monoclonal antibody.| Positive Control | HepG2, human colon |
|---|---|
| Application Notes | ICC:1:100-1:200 IHC:1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
