Application
Fig1: Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti- Caspase-1 Mouse mAb.Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti- Caspase-1 Mouse mAb.Application
Fig3: Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using anti- Caspase-1 Mouse mAb.Application
Fig4: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti- Caspase-1 Mouse mAb.Application
Fig5: ICC staining Caspase-1 in NIH/3T3 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Product Name | Caspase-1 [B0-6] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CASP-1 antibody CASP1 antibody CASP1_HUMAN antibody Caspase 1 antibody Caspase-1 subunit p10 antibody ICE antibody IL-1 beta-converting enzyme antibody IL-1BC antibody IL1 beta converting enzyme antibody IL1B convertase antibody Interleukin 1 beta convertase antibody Interleukin 1B converting enzyme antibody Interleukin-1 beta convertase antibody Interleukin-1 beta-converting enzyme antibody p45 antibody |
| Product description | Caspase 1 is produced as a?zymogen?that is cleaved into 20 kDa (p20) and 10 kDa (p10) subunits that become part of the active enzyme. Active caspase 1 contains two?heterodimers?of p20 and p10. It interacts with another?CARD domain?containing protein called?PYCARD?(or ASC) and is involved in?inflammasome?formation and activation of?inflammatory?processes. Caspase 1 has been shown to induce cell?necrosis?or?pyroptosis?and may function in various developmental stages. Studies of a similar protein in mouse suggest a role in the pathogenesis of?Huntington's disease.?Alternative splicing?of the gene results in five transcript variants encoding distinct isoforms.?Recent studies implicated caspase 1 in promoting CD4 T-cell death and inflammation by HIV, two signature events that fuel HIV disease progression to AIDS. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBICCIHC |
| WB:1:2,000-1:5,000 IHC:1:200-1:500 ICC:1:200 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | CASP-1 antibody CASP1 antibody CASP1_HUMAN antibody Caspase 1 antibody Caspase-1 subunit p10 antibody ICE antibody IL-1 beta-converting enzyme antibody IL-1BC antibody IL1 beta converting enzyme antibody IL1B convertase antibody Interleukin 1 beta convertase antibody Interleukin 1B converting enzyme antibody Interleukin-1 beta convertase antibody Interleukin-1 beta-converting enzyme antibody p45 antibody |
|---|---|
| Molecular Weight(MW) | 45kDa |
| Cellular Localization | Cytoplasm |
| SwissProt ID | P29466 |
|---|
Application
Fig1: Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti- Caspase-1 Mouse mAb.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti- Caspase-1 Mouse mAb.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using anti- Caspase-1 Mouse mAb.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti- Caspase-1 Mouse mAb.
Application
Fig5: ICC staining Caspase-1 in NIH/3T3 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Positive Control | Mouse heart, mouse spleen, human colon carcinoma tissue, human liver, NIH/3T3 |
|---|---|
| Application Notes | WB:1:2,000-1:5,000 IHC:1:200-1:500 ICC:1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
