Application
Fig3: ICC staining SHP1 in HCT116 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.Application
Fig3: ICC staining SHP1 in HCT116 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.Application
Fig3: ICC staining SHP1 in HCT116 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Product Name | SHP1 [B5-A4] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 70Z-SHP antibody EC 3.1.3.48 antibody HCP antibody HCPH antibody Hematopoietic cell phosphatase antibody Hematopoietic cell protein tyrosine phosphatase antibody Hematopoietic cell protein-tyrosine phosphatase antibody HPTP1C antibody Protein tyrosine phosphatase 1C antibody Protein tyrosine phosphatase non receptor type 6 antibody Protein tyrosine phosphatase SHP1 antibody Protein-tyrosine phosphatase 1C antibody protein-tyrosine phosphatase SHP 1 antibody Protein-tyrosine phosphatase SHP-1 antibody PTN6_HUMAN antibody PTP 1C antibody PTP-1C antibody PTP1C antibody Ptpn6 antibody SH PTP 1 antibody SH PTP1 antibody SH-PTP1 antibody SHP 1 antibody SHP 1L antibody SHP1 antibody SHP1L antibody tyrosine protein phosphatase non receptor type 6 antibody Tyrosine-protein phosphatase non-receptor type 6 antibody |
| Product description | Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene. SHP1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. SHP-1 gene has two promoters - P-1, active in epithelial cells, and P-2, active in hemopoietic cells. In addition the expression of SHP-1 is low in epithelial cells and high in hemopoetic cells. SHP-1 level in epithelial cells increases and in hematopoetic cells decreases in cancer. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Host Species | Mouse |
| Tested Applications | WBICCIHC |
| WB:1:500-1:1,000 IHC:1:200 ICC:1:200 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | 70Z-SHP antibody EC 3.1.3.48 antibody HCP antibody HCPH antibody Hematopoietic cell phosphatase antibody Hematopoietic cell protein tyrosine phosphatase antibody Hematopoietic cell protein-tyrosine phosphatase antibody HPTP1C antibody Protein tyrosine phosphatase 1C antibody Protein tyrosine phosphatase non receptor type 6 antibody Protein tyrosine phosphatase SHP1 antibody Protein-tyrosine phosphatase 1C antibody protein-tyrosine phosphatase SHP 1 antibody Protein-tyrosine phosphatase SHP-1 antibody PTN6_HUMAN antibody PTP 1C antibody PTP-1C antibody PTP1C antibody Ptpn6 antibody SH PTP 1 antibody SH PTP1 antibody SH-PTP1 antibody SHP 1 antibody SHP 1L antibody SHP1 antibody SHP1L antibody tyrosine protein phosphatase non receptor type 6 antibody Tyrosine-protein phosphatase non-receptor type 6 antibody |
|---|---|
| Molecular Weight(MW) | 68kDa |
| Cellular Localization | Cytoplasm, nucleus |
| SwissProt ID | P29350 |
|---|
Application
Fig3: ICC staining SHP1 in HCT116 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: ICC staining SHP1 in HCT116 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: ICC staining SHP1 in HCT116 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Positive Control | Mouse tonsil, human tonsil, mouse lymphoid tissue |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:200 ICC:1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
