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ALDH2 [E4-D10]

Catalog Number:OM638631
OM638631
Discount Price
OM638631-100ul
1~2 Week
100ul
OM638631-50ul
50ul
1~2 Week
Product Profile
Product Name ALDH2 [E4-D10]
Antibody Type Primary Antibodies
Antigen Alias Acetaldehyde dehydrogenase 2 antibody Aldehyde dehydrogenase 2 family (mitochondrial) antibody Aldehyde dehydrogenase 2 family antibody Aldehyde dehydrogenase mitochondrial antibody Aldehyde dehydrogenase, mitochondrial antibody ALDH 2 antibody ALDH class 2 antibody ALDH E2 antibody ALDH-E2 antibody Aldh2 antibody ALDH2_HUMAN antibody ALDHI antibody ALDM antibody Liver mitochondrial ALDH antibody MGC1806 antibody Mitochondrial aldehyde dehydrogenase 2 antibody MS767 antibody Nucleus encoded mitochondrial aldehyde dehydrogenase 2 antibody
Product description Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1A1, also designated retinal dehydrogenase 1 (RalDH1 or RALDH1); aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase cytosolic; ALDHII; ALDH-E1 or ALDH E1, is a retinal dehydrogenase that participates in the biosynthesis of retinoic acid (RA). The major liver isoform ALDH1 localizes to cytosolic space, while ALDH2 localizzes to the mitochondria. The ALDH1A2 (RALDH2, RALDH2-T) gene produces three different transcripts and also catalyzes the synthesis of RA from retinaldehyde. ALDH2 is present in most Caucasians, yet is absent in 50% of Asians. The absence of this enzyme has been linked to alcohol intolerance; and thusly, a reduced risk for alcoholism-related liver disease.
Immunogen peptide
Key Feature
Clonality Monoclonal
Isotype IgG1
Host Species Mouse
Tested Applications WBICC/IFIHCFC
WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
Species Reactivity HumanMouseRat
Concentration 2mg/ml
Target Information
Alternative Names Acetaldehyde dehydrogenase 2 antibody Aldehyde dehydrogenase 2 family (mitochondrial) antibody Aldehyde dehydrogenase 2 family antibody Aldehyde dehydrogenase mitochondrial antibody Aldehyde dehydrogenase
mitochondrial antibody ALDH 2 antibody ALDH class 2 antibody ALDH E2 antibody ALDH-E2 antibody Aldh2 antibody ALDH2_HUMAN antibody ALDHI antibody ALDM antibody Liver mitochondrial ALDH antibody MGC1806 antibody Mitochondrial aldehyde dehydrogenase 2 antibody MS767 antibody Nucleus encoded mitochondrial aldehyde dehydrogenase 2 antibody
Molecular Weight(MW) 56 kDa
Cellular Localization Mitochondrion matrix
Database Links
SwissProt ID P05091
Application

Application

Fig1: Western blot analysis on HepG2 cells lysates using anti-ALDH2 Mouse mAb.

Application

Fig2: Immunocytochemical staining of HepG2 cells using anti-ALDH2 Mouse mAb.

Application

Fig3: Immunocytochemical staining of PC-3M cells using anti-ALDH2 Mouse mAb.

Application

Fig4: Immunohistochemical analysis of paraffin- embedded human lung cancer tissue using anti-ALDH2 Mouse mAb.

Application

Fig5: Immunohistochemical analysis of paraffin- embedded human liver cancer tissue using anti-ALDH2 Mouse mAb.

Application

Fig6: Immunohistochemical analysis of paraffin- embedded human colon cancer tissue using anti-ALDH2 Mouse mAb.

Application

Fig7: Immunohistochemical analysis of paraffin- embedded human gastric cancer tissue using anti-ALDH2 Mouse mAb.

Application

Fig8: Immunohistochemical analysis of paraffin- embedded mouse colon tissue using anti-ALDH2 Mouse mAb.

Application

Fig9: Immunohistochemical analysis of paraffin- embedded mouse stomach tissue using anti-ALDH2 Mouse mAb.

Application

Fig10: Flow cytometric analysis of HepG2 cells with ALDH2 antibody at 1/100 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated Goat anti mouse IgG was used as the secondary antibody.
Positive Control HepG2, PC-3M, human colon cancer tissue, human lung cancer tissue, human gastric cancer tissue, human liver cancer tissue, mouse colon tissue, mouse stomach tissue.
Application Notes WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
Additional Information
Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
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