Application
Fig1: A.Western blot analysis of BACE expression in SH-SY5Y whole cell lysate.Application
Fig2： B.Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of glandular cells.| Product Name | BACE1 [7H4] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | APP beta secretase antibody Asp 2 antibody ASP2 antibody Aspartyl protease 2 antibody BACE 1 antibody BACE antibody BACE1 antibody BACE1_HUMAN antibody Beta secretase 1 antibody Beta secretase antibody Beta site amyloid beta A4 precursor protein cleaving enzyme antibody Beta site amyloid precursor protein cleaving enzyme 1 antibody Beta site amyloid precursor protein cleaving enzyme antibody Beta site APP cleaving enzyme 1 antibody Beta site APP cleaving enzyme antibody Beta-secretase 1 antibody Beta-site amyloid precursor protein cleaving enzyme 1 antibody Beta-site APP cleaving enzyme 1 antibody FLJ90568 antibody HSPC104 antibody Memapsin 2 antibody Memapsin-2 antibody Memapsin2 antibody Membrane associated aspartic protease 2 antibody Membrane-associated aspartic protease 2 antibody Transmembrane aspartic proteinase Asp2 antibody |
| Product description | Autosomal dominant Alzheimer’s disease is caused by mutations in the gene encoding the β-Amyloid protein precursor (APP). Amyloid β-peptide (Aβ), the major feature of amyloid plaques in Alzheimer’s patients, is the product of APP cleavage by β- and γ-secretases. BACE is the transmembrane protease which cleaves Aβ from APP. BACE and the related protein Asp1 are both widely expressed in human tissue, with the highest levels in the pancreas.BACE is localized within Golgi and endosomes. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIFIHC |
| WB:1:1,000 IP:1-2 μg per 100-500 μg of total protein IF:1:50-500 IHC:1:50-500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | APP beta secretase antibody Asp 2 antibody ASP2 antibody Aspartyl protease 2 antibody BACE 1 antibody BACE antibody BACE1 antibody BACE1_HUMAN antibody Beta secretase 1 antibody Beta secretase antibody Beta site amyloid beta A4 precursor protein cleaving enzyme antibody Beta site amyloid precursor protein cleaving enzyme 1 antibody Beta site amyloid precursor protein cleaving enzyme antibody Beta site APP cleaving enzyme 1 antibody Beta site APP cleaving enzyme antibody Beta-secretase 1 antibody Beta-site amyloid precursor protein cleaving enzyme 1 antibody Beta-site APP cleaving enzyme 1 antibody FLJ90568 antibody HSPC104 antibody Memapsin 2 antibody Memapsin-2 antibody Memapsin2 antibody Membrane associated aspartic protease 2 antibody Membrane-associated aspartic protease 2 antibody Transmembrane aspartic proteinase Asp2 antibody |
|---|---|
| Molecular Weight(MW) | 55.7 kDa |
| Cellular Localization | Membrane, Cytoplasmic vesicle membrane |
| SwissProt ID | P56817 |
|---|
Application
Fig1: A.Western blot analysis of BACE expression in SH-SY5Y whole cell lysate.
Application
Fig2： B.Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of glandular cells.| Positive Control | SH-SY5Y, human adrenal gland tissue. |
|---|---|
| Application Notes | WB:1:1,000 IP:1-2 μg per 100-500 μg of total protein IF:1:50-500 IHC:1:50-500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
