| Product Name | Beta-Arrestin 1 [4G6] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ARB1 antibody ARR1 antibody ARRB1 antibody ARRB1_HUMAN antibody Arrestin 2 antibody Arrestin beta 1 antibody Arrestin beta-1 antibody Beta-arrestin-1 antibody |
| Product description | The members of the G protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. Members of the β-Arrestin family regulate receptor binding to G proteins. β-Arrestins have been found to be located at postsynaptic sites, where they are thought to act in concert with βARK (βARK1, also designated GRK 2, or βARK2, also designated GRK 3) to regulate G protein-coupled neurotransmitter receptors. Expression of β-Arrestin-1 and β-Arrestin-2 is seen predominantly in spleen and neuronal tissues. It has been shown that β-Arrestin-1 expression is modulated by intracellular cAMP, which may be a novel mechanism for the regulation of receptor-mediated responses. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIP |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | ARB1 antibody ARR1 antibody ARRB1 antibody ARRB1_HUMAN antibody Arrestin 2 antibody Arrestin beta 1 antibody Arrestin beta-1 antibody Beta-arrestin-1 antibody |
|---|---|
| Molecular Weight(MW) | 55kDa |
| Cellular Localization | Cytoplasm, Nucleus, Cell membrane |
| SwissProt ID | P49407 |
|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
