Application
Fig1: Western blot analysis of CD151 expression in human platelet extract.Application
Fig2： Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing membrane and cytoplasmic staining of glandular cells.| Product Name | CD151 [3G1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CD151 antibody CD151 antigen antibody CD151 molecule (Raph blood group) antibody CD151 molecule antibody CD151_HUMAN antibody GP27 antibody hemidesmosomal tetraspanin CD151 antibody Membrane glycoprotein SFA-1 antibody MER2 antibody PETA-3 antibody PETA3 antibody Platelet endothelial tetraspan antigen 3 antibody platelet surface glycoprotein gp27 antibody Platelet-endothelial cell tetraspan antigen 3 antibody Platelet-endothelial tetraspan antigen 3 antibody RAPH antibody Red blood cell antigen MER2 antibody SFA 1 antibody SFA1 antibody Tetraspanin-24 antibody Tspan-24 antibody TSPAN24 antibody |
| Product description | CD151 is involved in a wide variety of cell biological processes, includingcell adhesion and the transport of integrins via vesicles. The human CD151gene maps to chromosome 11p15.5 and encodes a 253 amino acid protein,which belongs to the tetraspan (4TM) superfamily. CD151 can associate with several Integrin chains including β1, β3, β4, α2, α3, α5 and α6 integrins. CD151 may provide a framework for the spatial organization of both type I and type II hemidesmosomes, which are specialized junctional complexes that function as cell-attachment sites for binding to basement membranes. CD151 RNA transcript (1.6 kb) can be detected in MO7e cells, bone marrow stromal cells, C11 endothelial cells, HUVEC and several myeloid leukemia cell lines, however, no transcript is detected in brain and the lymphoblastoid cell lines MOLT-4 and BALM-1. Leu149 -Glu213 of CD151 is the interface through which Integrins α3/β1 can bind. CD151 can enhance cell motility, invasion and metastasis of cancer cells in a focal adhesion kinase dependent manner. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIFIHC-P |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-500 IHC:1:50-500 |
|
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | CD151 antibody CD151 antigen antibody CD151 molecule (Raph blood group) antibody CD151 molecule antibody CD151_HUMAN antibody GP27 antibody hemidesmosomal tetraspanin CD151 antibody Membrane glycoprotein SFA-1 antibody MER2 antibody PETA-3 antibody PETA3 antibody Platelet endothelial tetraspan antigen 3 antibody platelet surface glycoprotein gp27 antibody Platelet-endothelial cell tetraspan antigen 3 antibody Platelet-endothelial tetraspan antigen 3 antibody RAPH antibody Red blood cell antigen MER2 antibody SFA 1 antibody SFA1 antibody Tetraspanin-24 antibody Tspan-24 antibody TSPAN24 antibody |
|---|---|
| Molecular Weight(MW) | 28-32kDa |
| Cellular Localization | Cytoplasm, membrane |
| SwissProt ID | NP_001034579 |
|---|
Application
Fig1: Western blot analysis of CD151 expression in human platelet extract.
Application
Fig2： Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing membrane and cytoplasmic staining of glandular cells.| Positive Control | human prostate tissue |
|---|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-500 IHC:1:50-500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
