Application
Fig1: W Western blot analysis of GABAB R2 expression in mouse brain (A) and rat brain (B) tissue extracts.| Product Name | GABA(B) R2 [3G3] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BcDNA:GH07312 antibody CG6706 antibody CT20836 antibody D Gaba2 antibody FLJ36928 antibody G protein coupled receptor 51 antibody G-protein coupled receptor 51 antibody GAB B R2 antibody GABA B R2 antibody GABA B receptor 2 antibody GABA-B receptor 2 antibody GABA-B-R2 antibody GABA-BR2 antibody GABAB R2 antibody GABABR 2 antibody GABABR2 antibody GABB R2 antibody GABBR 2 antibody Gabbr2 antibody GABR2_HUMAN antibody Gamma aminobutyric acid B receptor 2 antibody Gamma aminobutyric acid GABA B receptor 2 antibody Gamma aminobutyric acid type B receptor subunit 2 antibody Gamma-aminobutyric acid type B receptor subunit 2 antibody Gb 2 antibody Gb2 antibody GH07312 antibody GPR 51 antibody GPR51 antibody GPRC 3B antibody GPRC3B antibody HG 20 antibody HG20 antibody HRIHFB2099 antibody Metabotropic GABA B receptor subtype 2 antibody OTTHUMP00000021776 antibody OTTHUMP00000063797 antibody R2 SUBUNIT antibody |
| Product description | In the central nervous system (CNS), γ-aminobutyric acid (GABA) is the maininhibitory neurotransmitter that functions to regulate neuronal firing. GABAexerts its effects through two different kinds of receptors: ionotropic receptors(GABAA R and GABAC R), which produce fast inhibitory signals, and metabotropicreceptors (GABAB R), which produce slow inhibitory signals. TheGABAB R receptor is a heterodimer that consists of two multi-pass membraneproteins, designated GABAB R1 and GABAB R2, both of which belong to theG protein-coupled receptor family and are highly expressed in brain tissue.Together, GABAB R1 and GABAB R2 play a crucial role in the fine-tuning ofinhibitory synaptic transmissions and are implicated in slow wave sleep,muscle relaxation, hippocampal long-term potentiation and antinociceptionevents. Both GABAB R1 and GABAB R2 are regulated by G proteins that havea variety of functions, including activation of potassium channels, inhibitionof adenylyl cyclase (A cyclase) activity and modulation of inositol phospholipidhydrolysis. |
| Immunogen | Amino acids 183-482 mapping within an extracellular domain of GABA(B) R2 of human origin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIF |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | BcDNA:GH07312 antibody CG6706 antibody CT20836 antibody D Gaba2 antibody FLJ36928 antibody G protein coupled receptor 51 antibody G-protein coupled receptor 51 antibody GAB B R2 antibody GABA B R2 antibody GABA B receptor 2 antibody GABA-B receptor 2 antibody GABA-B-R2 antibody GABA-BR2 antibody GABAB R2 antibody GABABR 2 antibody GABABR2 antibody GABB R2 antibody GABBR 2 antibody Gabbr2 antibody GABR2_HUMAN antibody Gamma aminobutyric acid B receptor 2 antibody Gamma aminobutyric acid GABA B receptor 2 antibody Gamma aminobutyric acid type B receptor subunit 2 antibody Gamma-aminobutyric acid type B receptor subunit 2 antibody Gb 2 antibody Gb2 antibody GH07312 antibody GPR 51 antibody GPR51 antibody GPRC 3B antibody GPRC3B antibody HG 20 antibody HG20 antibody HRIHFB2099 antibody Metabotropic GABA B receptor subtype 2 antibody OTTHUMP00000021776 antibody OTTHUMP00000063797 antibody R2 SUBUNIT antibody |
|---|---|
| Molecular Weight(MW) | 130 kDa |
| SwissProt ID | O75899 |
|---|
Application
Fig1: W Western blot analysis of GABAB R2 expression in mouse brain (A) and rat brain (B) tissue extracts.| Positive Control | mouse brain tissue, rat brain tissue. |
|---|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
