Application
Fig1: Western blot analysis of LRP6 expression in HeLa whole cell lysate.Application
Fig2： Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing membrane and cytoplasmic staining of glandular cells.| Product Name | LRP6 [1G8] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ADCAD2 antibody C030016K15Rik antibody Cd antibody FLJ90062 antibody FLJ90421 antibody Low density lipoprotein receptor related protein 6 antibody Low-density lipoprotein receptor-related protein 6 antibody LRP-6 antibody LRP6 antibody LRP6_HUMAN antibody OTTHUMP00000238979 antibody OTTHUMP00000238980 antibody OTTHUMP00000238982 antibody |
| Product description | LRP1, also designated α-2-macroglobulin receptor, is a endocytic receptor that mediates the uptake of at least 15 ligands, including α-2-macroglobulin and ApoE. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer’s disease (AD), as the human LRP1 gene localizes to a potential AD locus on chromosome 12. The human LRP6 gene localizes to chromosome 12p13.2 and encodes a protein with a unique pattern of four epidermal growth factor (EGF) and three LDLR repeats in the extracellular domain. LRP6 mediates Wnt/β-catenin signaling, which controls various developmental processes, including patterning of the body axis, central nervous system and limbs, and regulation of organogenesis. |
| Immunogen | Amino acids 1314-1613 of LRP6 of human origin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIFIHC-P |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 IHC:1:50-1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 2mg/ml |
| Alternative Names | ADCAD2 antibody C030016K15Rik antibody Cd antibody FLJ90062 antibody FLJ90421 antibody Low density lipoprotein receptor related protein 6 antibody Low-density lipoprotein receptor-related protein 6 antibody LRP-6 antibody LRP6 antibody LRP6_HUMAN antibody OTTHUMP00000238979 antibody OTTHUMP00000238980 antibody OTTHUMP00000238982 antibody |
|---|---|
| Molecular Weight(MW) | 183 kDa |
| Cellular Localization | Membrane, Endoplasmic reticulum |
| SwissProt ID | O75581 |
|---|
Application
Fig1: Western blot analysis of LRP6 expression in HeLa whole cell lysate.
Application
Fig2： Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing membrane and cytoplasmic staining of glandular cells.| Positive Control | Hela, human duodenum tissue. |
|---|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 IHC:1:50-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
