| Product Name | MDR1 [1G6] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ABC20 antibody ABCB1 antibody ATP binding cassette, sub family B (MDR/TAP), member 1 antibody ATP-binding cassette sub-family B member 1 antibody CD243 antibody CLCS antibody Colchicin sensitivity antibody Doxorubicin resistance antibody GP170 antibody MDR1 antibody MDR1_HUMAN antibody Multidrug resistance 1 antibody Multidrug resistance protein 1 antibody P glycoprotein 1 antibody P gp antibody P-glycoprotein 1 antibody PGY1 antibody |
| Product description | Cells selected for resistance to a single cytotoxic drug may become cross-resistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). The MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance observed in human cancer cells following prolonged chemotherapy. The classic form of MDR is associated with an increase in the Mdr protein, but not all cases of MDR can be attributed to a rise in Mdr levels. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. In the human population, there are 15 polymorphisms in the Mdr-1 gene. |
| Immunogen | Mdr of hamster origin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIF |
| WB:1:10-1:200 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:10-1:200 IHC:1:10-1:200 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | ABC20 antibody
ABCB1 antibody
ATP binding cassette sub family B (MDR/TAP) member 1 antibody ATP-binding cassette sub-family B member 1 antibody CD243 antibody CLCS antibody Colchicin sensitivity antibody Doxorubicin resistance antibody GP170 antibody MDR1 antibody MDR1_HUMAN antibody Multidrug resistance 1 antibody Multidrug resistance protein 1 antibody P glycoprotein 1 antibody P gp antibody P-glycoprotein 1 antibody PGY1 antibody |
|---|---|
| Molecular Weight(MW) | 170 kDa |
| Cellular Localization | Cell membrane |
| SwissProt ID | P08183 |
|---|
| Application Notes | WB:1:10-1:200 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:10-1:200 IHC:1:10-1:200 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
