Application
Fig1: Western blot analysis of TAL1 expression in non-transfected (A) and human TAL1 transfected (B) 293T whole cell lysates and CCRF-CEM (C), Jurkat (D) and K-562 (E) nuclear extracts.| Product Name | TAL1 / SCL LS-C182473 [4G1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | bHLHa17 antibody Class A basic helix-loop-helix protein 17 antibody OTTHUMP00000009563 antibody OTTHUMP00000009564 antibody SCL antibody STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR antibody Stem cell protein antibody T cell acute lymphocytic leukemia 1 antibody T cell acute lymphocytic leukemia 1 protein antibody T cell acute lymphocytic leukemia 1 protein antibody T cell leukemia/lymphoma 5 protein antibody T-cell acute lymphocytic leukemia protein 1 antibody T-cell leukemia/lymphoma protein 5 antibody Tal 1 antibody Tal 1 product antibody TAL 1 protein antibody TAL-1 antibody tal1 antibody TAL1_HUMAN antibody TCL 5 antibody TCL5 antibody |
| Product description | Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic coexpression of TAL1 and the catalytic subunit of casein kinase IIα, a serine/ threonine protein kinase known to modulate the activity of other βHLH transcription factors. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIF |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | bHLHa17 antibody Class A basic helix-loop-helix protein 17 antibody OTTHUMP00000009563 antibody OTTHUMP00000009564 antibody SCL antibody STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR antibody Stem cell protein antibody T cell acute lymphocytic leukemia 1 antibody T cell acute lymphocytic leukemia 1 protein antibody T cell acute lymphocytic leukemia 1 protein antibody T cell leukemia/lymphoma 5 protein antibody T-cell acute lymphocytic leukemia protein 1 antibody T-cell leukemia/lymphoma protein 5 antibody Tal 1 antibody Tal 1 product antibody TAL 1 protein antibody TAL-1 antibody tal1 antibody TAL1_HUMAN antibody TCL 5 antibody TCL5 antibody |
|---|---|
| Molecular Weight(MW) | 42kDa |
| Cellular Localization | Nucleus |
| SwissProt ID | P17542 |
|---|
Application
Fig1: Western blot analysis of TAL1 expression in non-transfected (A) and human TAL1 transfected (B) 293T whole cell lysates and CCRF-CEM (C), Jurkat (D) and K-562 (E) nuclear extracts.| Positive Control | 293T, CCRF-CEM, Jurkat, K-562 |
|---|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
