Application
Fig1: Western blot analysis of TNF-R1 expression in MCF7 (A), HeLa (B) and U-937 (C) whole cell lysates.Application
Fig2： Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.| Product Name | TNFR1 [2G2] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CD120a antibody FPF antibody MGC19588 antibody p55 antibody p55-R antibody p60 antibody TBP1 antibody TBPI antibody TNF R antibody TNF R55 antibody TNF-R1 antibody TNF-RI antibody TNFAR antibody TNFR-I antibody TNFR1 antibody TNFR55 antibody TNFR60 antibody TNFRI antibody TNFRSF1a antibody TNR1A_HUMAN antibody Tumor necrosis factor receptor 1 antibody Tumor necrosis factor receptor superfamily, member 1A antibody Tumor necrosis factor receptor type 1 antibody Tumor necrosis factor receptor type I antibody Tumor necrosis factor-binding protein 1 antibody |
| Product description | Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors. These receptors, designated TNF-R1 and TNF-R2 are expressed on most cell types. The majority of TNF functions are primarily mediated through TNF-R1, while signaling through TNF-R2 occurs less extensively and is confined to cells of the immune system. Both of these proteins belong to the growing TNF and nerve growth factor (NGF) receptor superfamily, which includes FAS, CD30, CD27 and CD40. The members of this superfamily are type I membrane proteins that share sequence homology confined to the extracellular region. TNF-R1 shares a motif coined the “death domain” with FAS and three structurally unrelated signaling proteins, TRADD, FADD and RIP. This “death domain” is required for transduction of the apoptotic signal. |
| Immunogen | Amino acids 30-301 mapping within the extracellular domain of TNF-R1 of human origin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Mouse |
| Tested Applications | WBIPIFIHC-P |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 IHC:1:50-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | CD120a antibody
FPF antibody
MGC19588 antibody
p55 antibody
p55-R antibody
p60 antibody
TBP1 antibody
TBPI antibody
TNF R antibody
TNF R55 antibody
TNF-R1 antibody
TNF-RI antibody
TNFAR antibody
TNFR-I antibody
TNFR1 antibody
TNFR55 antibody
TNFR60 antibody
TNFRI antibody
TNFRSF1a antibody
TNR1A_HUMAN antibody
Tumor necrosis factor receptor 1 antibody
Tumor necrosis factor receptor superfamily member 1A antibody Tumor necrosis factor receptor type 1 antibody Tumor necrosis factor receptor type I antibody Tumor necrosis factor-binding protein 1 antibody |
|---|---|
| Molecular Weight(MW) | 55 kDa |
| Cellular Localization | Secreted, Golgi apparatus membrane Cell membrane |
| SwissProt ID | P19438 |
|---|
Application
Fig1: Western blot analysis of TNF-R1 expression in MCF7 (A), HeLa (B) and U-937 (C) whole cell lysates.
Application
Fig2： Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.| Positive Control | Hela, MCF7, U-937, human small intestine tissue. |
|---|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 IHC:1:50-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
