WB
Western blot analysis using ATF6 antibody against A549 (1), MCF-1 (2) cell lysate.IHC
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissues using ATF6 antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using ATF6 antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human kidney tissues using ATF6 antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human stomach cancer tissues using ATF6 antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human thyroid carcinoma tissues using ATF6 antibody with DAB staining.WB
Western blot analysis using ATF6 antibody against Mouse brain(1) tissue.| Product Name | Anti-ATF6 antibody-HRP |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | HRP |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:200-1:2000 IHC:1:100-1:1000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | ATF6 |
|---|---|
| Gene Synonyms | ACHM7 ATF6A |
| Gene Full Name | activating transcription factor 6 |
| Gene Summary | This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011] |
| Molecular Weight(MW) | 75 KDa |
| Source | Rabbit |
| Cellular Localization | Endoplasmic reticulum membrane and Nucleus. |
| SwissProt ID | P18850 |
|---|
WB
Western blot analysis using ATF6 antibody against A549 (1), MCF-1 (2) cell lysate.
IHC
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissues using ATF6 antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using ATF6 antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human kidney tissues using ATF6 antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human stomach cancer tissues using ATF6 antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human thyroid carcinoma tissues using ATF6 antibody with DAB staining.
WB
Western blot analysis using ATF6 antibody against Mouse brain(1) tissue.| Application Notes | WB:1:200-1:2000 IHC:1:100-1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
