| Product Name | Anti-Phospho-ATF6 (Thr166) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Thr166 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ATF6 |
|---|---|
| Gene Synonyms | ACHM7 ATF6A ATP6alpha |
| Gene Full Name | activating transcription factor 6 |
| Gene Summary | This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011] |
| Alternative Names | Activating transcription factor 6 alpha Activating transcription factor 6 ATF 6 ATF6 alpha ATF6 ATF6-alpha ATF6A ATF6A_HUMAN cAMP dependent transcription factor ATF 6 alpha cAMP-dependent transcription factor ATF-6 alpha Cyclic AMP dependent transcription factor ATF 6 alpha DKFZp686P2194 ESTM49 FLJ21663 Processed cyclic AMP dependent transcription factor ATF 6 alpha Processed cyclic AMP-dependent transcription factor ATF-6 alpha |
| Molecular Weight(MW) | 75 kDa |
| Cellular Localization | Endoplasmic reticulum,Golgi apparatus,Membrane,Nucleus. |
| SwissProt ID | P18850 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
