| Function |
Protein kinases catalyze the phosphorylation of serine, threonine or tyrosine
residues in target substrates, providing a mechanism of control for myriad
cellular signaling pathways. Several families of kinases phosphorylate both
serine and threonine residues in target substrates, including the Raf, Rsk,
ROCK, PAK, Ak and PKC families of serine/threonine protein kinases. The
modification of proteins by phosphorylation can result in three dimensional
changes to the structure of the protein and thereby alter its enzymatic activity
or its ability to interact with other proteins. Antibodies targeted to phos
phoserine may be used for the characterization of proteins with phosphory
lated serine residues, and for the elucidation of cellular pathways involving
serine phosphorylation. |
