| Product Name | Mouse Monoclonal antibody to Phosphatidylinositol 4,5-biphosphate (PIP2) |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | raised against liposomes of human origin. |
| Clonality | monoclonal |
|---|---|
| Isotype | IgM,k |
| Host Species | Mouse |
| Tested Applications | IFIP |
| IF:1:50-1:500 IP:1-2 µg per 100-500 µg of total protein (1 ml of cell lysate) |
|
| Species Reactivity | Human |
| Concentration | 0.2mg/ml |
| Purification | Affinity purified |
| Function | Phosphatidylinositol 4,5-biphosphate (PIP2) is a low-abundance membrane phospholipid that functions in a variety of cellular processes, such as mem brane trafficking, plasma membrane-cytoskeleton linkages, synaptic vesicle recycling, second messenger signaling, cell adhesion and motility and regula tion of proteins involved in phospholipid metabolism. It also stimulates the Ca2+-activated ATPase, implicating that changes in the cellular concentration of PIP2 may be important in regulating Ca2+ transport by the endoplasmic reti- culum. PIP2 and intracellular Ca2+ regulate the taste transduction ion channel TRPM5. PIP2 serves as an effector of multiple downstream proteins and its levels are regulated by hormones. It may also serve as a second messenger in the control of cytoskeleton-membrane adhesion. |
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| Application Notes | IF:1:50-1:500 IP:1-2 µg per 100-500 µg of total protein (1 ml of cell lysate) |
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| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4° C, **DO NOT FREEZE**. Stable for one year from the date of shipment. Non-hazardous. No MSDS required. |
| Storage Buffer | Each vial contains 200 µg IgG1 kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin. |
