A synthesized peptide derived from human Caspase-2.
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ICC/IFIHCWB
WB:1:500-1:2000 IHC:1:50-1:200 ICC/IF:1:50-1:200
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Symbol
CASP2
Gene Synonyms
ICH1 MRT80 NEDD2 CASP-2 NEDD-2 PPP1R57
Gene Full Name
caspase 2
Gene Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Molecular Weight(MW)
48kDa 30kDa
Cellular Localization
cytoplasm,cytosol,nucleus.
Application
WB
Western blot analysis of Caspase-2 expression in Jurkat cell lysate.
IHC
Immunohistochemical analysis of paraffin-embedded mouse testis, using Caspase-2 Antibody.
ICC/IF
Immunofluorescent analysis of Hela cells, using Caspase-2 Antibody.
Application Notes
WB:1:500-1:2000 IHC:1:50-1:200 ICC/IF:1:50-1:200
Additional Information
Form
Liquid
Storage Instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Storage Buffer
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.