Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP)
Antibody Type
Primary Antibodies
Immunogen
Recombinant LBP (Asn27~Val481) expressed in E.coli
Key Feature
Clonality
Monoclonal
Isotype
IgG1, k
Host Species
Mouse
Tested Applications
IHCWB
IHC:5-20µg/mL WB:1:200-1:2000
Species Reactivity
Human
Concentration
1mg/ml
Purification
Protein A/G
Target Information
Gene Symbol
LBP
Gene Synonyms
BPIFD2
Gene Full Name
lipopolysaccharide binding protein
Gene Summary
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
Alternative Names
LPS-Binding Protein
Molecular Weight(MW)
52 kDa
Application
WB
Figure. Western Blot; Sample: Recombinant LBP, Human.
IHC
DAB staining on IHC-P; Sample: Human Kidney Tissue; Primary Ab: 10µg/ml Mouse Anti-Human LBP Antibody Second Ab: 2µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody.
Application Notes
IHC:5-20µg/mL WB:1:200-1:2000
Additional Information
Form
Liquid
Storage Instructions
Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 24 months.
Storage Buffer
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300,50% glycerol.