WB
Western blot analysis of extracts from Human plasma tissue using alpha 2 Macroglobulin Rabbit mAb at 1:1000.| Product Name | alpha 2 Macroglobulin Rabbit mAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | A synthetic peptide of human alpha 2 Macroglobulin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:1000-1:5000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | A2M |
|---|---|
| Gene Synonyms | A2MD CPAMD5 FWP007 S863-7 |
| Gene Full Name | alpha-2-macroglobulin |
| Gene Summary | The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016] |
| Alternative Names | A2MD CPAMD5 FWP007 S863-7 |
| Molecular Weight(MW) | 163 kDa |
| Cellular Localization | Secreted. |
WB
Western blot analysis of extracts from Human plasma tissue using alpha 2 Macroglobulin Rabbit mAb at 1:1000.| Application Notes | WB:1:1000-1:5000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20°C.Stable for 12 months from date of receipt. |
| Storage Buffer | Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
