IHC
Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200.IHC
Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200.| Product Name | MLL Rabbit pAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide from human protein at AA range: 3850-3900. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KMT2A |
|---|---|
| Gene Synonyms | HRX MLL ALL1 GAS7 HTRX MLL1 TRX1 ALL-1 CXXC7 HTRX1 MLL1A WDSTS |
| Gene Full Name | lysine methyltransferase 2A |
| Gene Summary | This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010] |
| Alternative Names |
MLL ALL1 CXXC7 HRX HTRX KMT2A MLL1 TRX1 Histone-lysine N-methyltransferase MLL ALL-1 CXXC-type zinc finger protein 7 Lysine N-methyltransferase 2A KMT2A Trithorax-like protein Zinc finger protein HRX [Cleaved into: MLL cleavage product N320 N-terminal cleavage product of 320 kDa p320 MLL cleavage product C180 C-terminal cleavage product of 180 kDa p180 |
| Molecular Weight(MW) | 432 kDa |
| Cellular Localization | Nucleus .; [MLL cleavage product N320]: Nucleus.; [MLL cleavage product C180]: Nucleus. Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320. |
IHC
Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200.
IHC
Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200.| Application Notes | IHC:1:100-1:300 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | -15°C to -25°C/1 year (Do not lower than -25°C). |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
