WB
Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was incubated with anti-CD204 antibody at a dilution of 1:500. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody.IHC
Human spleen was stained with anti-CD204 Rabbit antibody.IHC
Mouse spleen was stained with anti-CD204 Rabbit antibody.| Product Name | CD204 Rabbit mAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG,K |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| WB:1:500-1:2000 IHC:1:200-1:1000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | MSR1 |
|---|---|
| Gene Synonyms | SRA SR-A CD204 SR-AI phSR1 phSR2 SCARA1 SR-AII SR-AIII |
| Gene Full Name | macrophage scavenger receptor 1 |
| Gene Summary | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] |
| Alternative Names |
Macrophage scavenger receptor types I and II Macrophage acetylated LDL receptor I and II Scavenger receptor class A member 1 CD antigen CD204 |
| Molecular Weight(MW) | 50 kDa(Observed band size: 80 kDa) |
| Cellular Localization | Membrane; Single-pass type II membrane protein. |
| SwissProt ID | P21757 |
|---|
WB
Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was incubated with anti-CD204 antibody at a dilution of 1:500. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody.
IHC
Human spleen was stained with anti-CD204 Rabbit antibody.
IHC
Mouse spleen was stained with anti-CD204 Rabbit antibody.| Application Notes | WB:1:500-1:2000 IHC:1:200-1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | -15°C to -25°C/1 year (Do not lower than -25°C). |
| Storage Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA. |
