This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Mice lacking a functional copy of this gene exhibit impaired immune cell-mediated cytolysis. [provided by RefSeq, Sep 2016]
Alternative Names
alternatively spliced cathepsin G-like 1 cathepsin G-like 2 protein h-CCPX CGL-2 CGL2 CTLA1 cytotoxic cell protease 1 cytotoxic serine protease B cytotoxic T-lymphocyte proteinase cytotoxic T-lymphocyte proteinase 2 cytotoxic T-lymphocyte-associated serine esterase 1 cytotoxin serine protease-C cytotoxin serine protease-C precursor fragmentin fragmentin 2 fragmentin-2 GLP I GLP III GLP-1 granzyme B (granzyme 2 cytotoxic T-lymphocyte-associated serine esterase 1) granzyme-like protein 1 granzyme-like protein I Gzmb GZMH GZMH/GZMB human lymphocyte protein natural killer cell protease 1 proteolytic serine esterase serine protease serine protease-like protein precursor T-cell serine protease 1-3E T-cell specific protein CCPI precursor