Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
Alternative Names
AT-HSFB1 ATHSF4 binds heat shock DNA elements cataract DNA binding protein heat shock factor 4 hHSF4 HSF 4 HSFB1 HSTF 4 Marner