SET domain containing 2, histone lysine methyltransferase
Gene Summary
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
Alternative Names
contains WW domain FLJ16420 FLJ22472 FLJ23184 FLJ45883 huntingtin interacting protein 1 huntingtin yeast partner B huntingtin-interacting protein B HYPB contains WW domain lysine N-methyltransferase 3A protein-lysine N-methyltransferase SETD2 SET domain-containing protein 2