This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Alternative Names
cellular myosin heavy chain type A flectin MGC104539 motor protein MYH9 myosin heavy chain IX myosin IIA myosin heavy chain 9 non-muscle myosin9 NMHC-II A NMMHC IIA non-muscle myosin heavy chain 9 non-muscle myosin heavy chain A non-muscle myosin heavy chain IIa non-muscle myosin heavy polypeptide 9 nonmuscle myosin heavy chain (NMHC) nonmuscle myosin heavy chain II-A nonmuscle myosin IIA2