This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
Alternative Names
cadherin family member 7 cadherin ME5 cadherin-related family member 8 cadherin-related tumor suppressor homolog fat 1 cadherin FAT tumor suppressor 1 FAT tumor suppressor homolog 1 FAT1 FAT1+12 FAT1+32 FAT1+8TR protein fat homolog