The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]
Alternative Names
atrial natriuretic factor atrial natriuretic factor prohormone atrial natriuretic peptide prohormone atriopeptigen atriopeptin cardiodilatin cardiodilatin-related peptide cardionatrin natriuretic peptide precursor A Natriuretic peptide precursor A (pronatriodilatin also Anf Pnd) natriuretic peptide precursor type A preproANF preproANP preprocardiodilatin-atrial natriuretic factor preproCDD-ANF prepronatiodilatin (PND) prepronatriodilatin proANF proANP Pronatriodilatin urodilatin